Measuring human carboxylesterase 2 activity in pancreatic cancer patient-derived xenografts using a ratiometric fluorescent chemosensor
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چکیده
منابع مشابه
A near-infrared and ratiometric fluorescent chemosensor for palladium.
A near-infrared chemosensor for palladium based on the Tsuji-Trost reaction was developed. It displayed specific and ratiometric fluorescent responses toward palladium with a distinct color change from green to blue in aqueous media. PEG400 was employed as the reducing agent and palladium ligand instead of water-insoluble triphenylphosphine. The chemosensor's bioimaging potential was demonstrat...
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BACKGROUND Polo-like kinase 4 (PLK4) plays a key role in centriole replication. Hence PLK4 inhibition disrupts mitosis, and offers a novel approach to treating chromosomally unstable cancers, including pancreatic cancer. CFI-400945 is a first in class small molecule PLK4 inhibitor, currently undergoing early phase clinical trials. RESULTS Treatment with CFI-400945 significantly reduced tumor ...
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ژورنال
عنوان ژورنال: Chemical Science
سال: 2019
ISSN: 2041-6520,2041-6539
DOI: 10.1039/c9sc00283a